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Related Experiment Videos

Two anaphylactic deaths after chemonucleolysis.

V J DiMaio

    Journal of Forensic Sciences
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Chemonucleolysis using chymopapain for low back pain can cause anaphylaxis. This paper details the only two known fatalities from anaphylactic reactions following this disc treatment.

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    Area of Science:

    • Medicine
    • Anesthesiology
    • Neurosurgery

    Background:

    • Chemonucleolysis is a treatment for discogenic low back pain.
    • Chymopapain injection dissolves the nucleus pulposus in lumbar discs.
    • Over 15,000 patients worldwide have undergone chemonucleolysis.

    Observation:

    • Anaphylaxis, a severe allergic reaction, occurs in approximately 1% of chemonucleolysis cases.
    • This paper reports the only two known fatalities attributed to anaphylaxis post-chymopapain injection.
    • Both patients experienced sudden hypotension after the procedure.

    Findings:

    • One patient succumbed rapidly to anaphylaxis.
    • The second patient died from complications arising from prolonged shock.
    • These cases represent the sole documented deaths from anaphylaxis linked to chemonucleolysis.

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    Implications:

    • Highlights the critical need for vigilance regarding anaphylaxis in chemonucleolysis procedures.
    • Underscores the importance of immediate management protocols for hypotensive events post-injection.
    • Suggests a review of patient selection and monitoring for chymopapain treatment.