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Cutaneous Waldenström's macroglobulinaemia.

I Chan1, E Calonje, S J Whittaker

  • 1St John's Institute of Dermatology, St Thomas' Hospital, London. ien.chan@kcl.ac.uk

Clinical and Experimental Dermatology
|September 3, 2003
PubMed
Summary

Waldenström's macroglobulinaemia can rarely present initially with skin lesions like nodules and plaques. This rare cutaneous presentation occurred without any systemic symptoms in the reported case.

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Area of Science:

  • Hematology
  • Dermatology
  • Oncology

Background:

  • Waldenström's macroglobulinaemia (WM) is a rare lymphoproliferative disorder.
  • Cutaneous manifestations in WM are typically secondary to hyperviscosity or immunoglobulin deposition.
  • Direct skin infiltration by malignant lymphocytes is an uncommon feature of WM.

Observation:

  • A case of Waldenström's macroglobulinaemia is presented.
  • The patient exhibited infiltrated skin nodules and plaques as the primary manifestation.
  • Notably, the patient lacked any systemic symptoms at presentation.

Findings:

  • This case highlights a rare initial presentation of Waldenström's macroglobulinaemia.
  • The cutaneous findings were due to direct infiltration of neoplastic lymphoid cells.
  • The absence of systemic symptoms at presentation is unusual for WM.

Implications:

  • Recognizing rare cutaneous presentations is crucial for early diagnosis of Waldenström's macroglobulinaemia.
  • This case expands the understanding of WM's clinical spectrum.
  • Dermatologists and hematologists should consider WM in the differential diagnosis of unexplained skin infiltrates.

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