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Published on: May 1, 2015
Leukocytoclastic (small vessel) vasculitis in multiple myeloma
I B Bayer-Garner1, B R Smoller
1Department of Pathology, Marshfield Clinic, Marshfield, WI, USA.
Clinical and Experimental Dermatology
|September 3, 2003
Summary
Leukocytoclastic vasculitis (LCV), a condition marked by palpable purpura, rarely occurs with multiple myeloma (MM). This study found eight cases of LCV in MM patients, suggesting a link possibly involving Interleukin 6.
Area of Science:
- Hematology
- Immunology
- Dermatology
Background:
- Leukocytoclastic vasculitis (LCV) is characterized by palpable purpura and neutrophilic inflammation of small blood vessels.
- While LCV has various associations, its occurrence with multiple myeloma (MM) is rare.
- Understanding this association is crucial for comprehensive patient management.
Purpose of the Study:
- To investigate the association between multiple myeloma (MM) and leukocytoclastic vasculitis (LCV).
- To identify specific characteristics of LCV in patients with MM.
- To explore potential pathogenetic links between MM and LCV.
Main Methods:
- Retrospective review of 2357 patients diagnosed with multiple myeloma (MM).
- Identification of patients who developed leukocytoclastic vasculitis (LCV).
- Analysis of clinical and histological features of identified cases.
Main Results:
- Eight patients with a diagnosis of MM also developed LCV.
- The identified cases predominantly showed immunoglobulin G (IgG) myeloma.
- Results paralleled the overall immunoglobulin secretion patterns observed in MM.
Conclusions:
- A rare but notable association exists between multiple myeloma (MM) and leukocytoclastic vasculitis (LCV).
- Immunoglobulin G (IgG) myeloma appears to be more common in patients with both conditions.
- Overexpression of Interleukin 6 in MM may play a role in the pathogenesis of LCV.
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