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Enhanced activation of CD83-positive T cells

M Wolenski1, S O Cramer, S Ehrlich

  • 1Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.

Scandinavian Journal of Immunology
|September 3, 2003
PubMed

CD83 is a marker molecule for mature dendritic cells (DCs) but is also substantially expressed on activated T cells in humans and mice. Its function is unknown, but CD83 knockout mice show an impaired thymic maturation of CD4-positive cells and soluble CD83 inhibits partially antigen-specific responses in vitro pointing to a role of CD83 in the immune system. Here we show that CD83-positive T cells produce strongly increased amounts of interferon-gamma and interleukin-2. In contrast, constitutive expression of CD83 on DCs alters neither the activation of DCs following addition of lipopolysaccharide nor the ability to present antigenic peptides. Thus, the expression of CD83 on T cells has direct functional consequences for tuning the activation threshold.

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