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Extracorporeal albumin dialysis in patients with Amanita phalloides poisoning

Peter Faybik1, Hubert Hetz, Amir Baker

  • 1Department of Anesthesia and Intensive Care Medicine, University Hospital, Vienna, Austria. zralok@hotmail.com

Liver International : Official Journal of the International Association for the Study of the Liver
|September 3, 2003
PubMed
Abstract

Insights

Extracorporeal albumin dialysis (ECAD) shows promise for treating severe Amanita phalloides mushroom poisoning. This method aids liver regeneration or bridges patients to liver transplantation, improving outcomes in acute liver failure.

Area of Science:

  • Toxicology
  • Hepatology
  • Nephrology

Background:

  • Amanita phalloides mushroom poisoning is a leading cause of fatal poisoning.
  • Delayed symptom onset complicates toxin removal, increasing mortality risk.

Observation:

  • Six patients with acute liver failure due to A. phalloides poisoning received extracorporeal albumin dialysis (ECAD).
  • Treatments were administered 76 hours post-ingestion on average.

Findings:

  • Two patients avoided liver transplantation through spontaneous regeneration during ECAD.
  • Two patients were successfully bridged to orthotopic liver transplantation (OLT).
  • One patient died from cerebral herniation; another survived OLT with graft dysfunction treated by ECAD.

Implications:

  • ECAD is a viable treatment for A. phalloides poisoning, supporting liver regeneration.
  • ECAD can serve as a bridge to OLT or manage post-transplant graft dysfunction.
  • This approach offers a new therapeutic avenue for severe mushroom poisoning and liver failure.

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