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Determinants of histamine recognition: implications for the design of antihistamines
V Badireenath Konkimalla1, Nagasuma Chandra
1Bioinformatics Centre, Indian Institute of Science, Bangalore 560 012, India.
Biochemical and Biophysical Research Communications
|September 3, 2003
Abstract:
Towards understanding how histamine, a vital neurotransmitter, can perform multiple physiological tasks, an analysis of the different proteins that bind histamine is reported here. Their structural comparison reveals conformational rigidity of histamine. Yet, flexibility in the modes of histamine binding has been observed, which appears to suit specific biological roles of the proteins. These results will be helpful in developing specific antihistamines and also in understanding the pharmacological and toxicological profiles of existing antihistamines.