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Updated: Aug 4, 2026

Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core
Published on: October 24, 2017
Design and synthesis of fluorinated RXR modulators
D L Gernert1, R Ajamie, R A Ardecky
1Discovery Chemistry Research, Lilly Research Laboratories, Indianapolis, IN, USA. dgernert@lilly.com
Abstract:
Fluorinated trienoic acid analogues of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRalpha and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the position of fluorination, and improvement in pharmacological profile was demonstrated in some cases.
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