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Updated: Sep 20, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class
Constantine G Boojamra1, Rémy C Lemoine, Johanne Blais
1Essential Therapeutics, Inc. (formerly Microcide Pharmaceuticals, Inc.), 850 Maude Avenue, Mountain View, CA 94043, USA. dboojamra@gilead.com
Abstract:
Dihydropacidamycins having an antibacterial spectrum modified from that of the natural product pacidamycins and mureidomycins have been synthesized. Synthetic dihydropacidamycins with noteworthy antibacterial activity against wild-type and resistant Escherichia coli have been identified (MIC=4-8 microg/mL). Some dihydropacidamycins are shown to have activity against multi-resistant clinical strains of Mycobacterium tuberculosis. Compounds of this class are inhibitors of the cell wall biosynthetic enzyme, MraY.
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