Related Experiment Videos
Structure activity studies of a novel cytotoxic benzodiazepine
Anthony Boitano1, Cory D Emal, Francesco Leonetti
1Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109-1055, USA.
Bioorganic & Medicinal Chemistry Letters
|September 3, 2003
Abstract:
Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity.