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A path to improved pharmaceutical productivity.

Carl M Cohen1

  • 1carlmcohen@hotmail.com

Nature Reviews. Drug Discovery
|September 3, 2003
PubMed
Summary
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Metrics-driven approaches in pharmaceutical drug discovery are failing. A cooperative approach using performance metrics offers a path toward fundamental industry improvement and enhanced drug development productivity.

Area of Science:

  • Pharmaceutical Sciences
  • Biotechnology
  • Drug Discovery and Development

Background:

  • Current metrics-driven strategies in pharmaceutical R&D are insufficient for enhancing drug discovery productivity.
  • Existing performance metrics do not adequately capture the complexities of the drug discovery pipeline.

Approach:

  • Proposes a novel framework for utilizing performance metrics grounded in inter-industry cooperation.
  • Emphasizes collaborative data sharing and standardized metric development across pharmaceutical organizations.

Key Points:

  • Metrics must evolve beyond simple output measures to reflect true innovation and success rates.
  • Cooperation is essential for developing robust, universally applicable performance metrics.
  • A shift towards shared learning and collaborative goal-setting can drive significant industry-wide improvements.

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Conclusions:

  • The current trajectory of metrics-driven pharmaceutical R&D is unsustainable and requires a paradigm shift.
  • Implementing a cooperative performance metrics strategy can foster innovation and accelerate the delivery of novel therapeutics.
  • This approach promises to guide fundamental improvements in the efficiency and effectiveness of drug discovery.