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Related Experiment Videos

Lipoxygenase activity in altered gravity.

Mauro Maccarrone1, Natalia Battista, Monica Bari

  • 1Department of Experimental Medicine and Biochemical Sciences and Biomedical Space Center, University of Rome Tor Vergata, Rome, Italy.

Advances in Space Biology and Medicine
|September 4, 2003
PubMed
Summary

Microgravity alters lipoxygenase enzyme activity, impacting cellular processes like apoptosis and immune response. This research explores lipoxygenase and cyclooxygenase roles in space-related conditions.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Space Biology

Background:

  • Lipoxygenases (LOX) are enzymes catalyzing fatty acid dioxygenation, crucial in cellular signaling and pathophysiological conditions.
  • LOX activity is vital in both animal and plant systems, influencing membrane lipoperoxidation and metabolic pathways.
  • Understanding LOX function is key to addressing cellular changes in various environments.

Purpose of the Study:

  • To review the effects of microgravity on lipoxygenase activity and expression.
  • To investigate the role of lipoxygenases in space-related cellular processes such as apoptosis and immune suppression.
  • To examine cyclooxygenase (COX) modulation in response to altered gravity.

Main Methods:

  • Assessing catalytic efficiency of purified soybean lipoxygenase-1 under microgravity.

Related Experiment Videos

  • Analyzing 5-lipoxygenase activity and expression in human K562 cells under altered gravity.
  • Evaluating cyclooxygenase activity and expression in K562 cells exposed to altered gravity.

    • Main Results:

    • Microgravity impacts the catalytic efficiency of soybean lipoxygenase-1.
    • Altered gravity modulates the activity and expression of 5-lipoxygenase in human K562 cells.
    • Cyclooxygenase activity and expression are also affected by altered gravity in K562 cells.

    Conclusions:

    • Lipoxygenases and cyclooxygenases are sensitive to microgravity, suggesting a role in space-related cellular responses.
    • These enzymes may be involved in space-induced apoptosis and immuno-depression.
    • Further research is needed to fully elucidate the implications of altered gravity on these enzymatic pathways.