Related Experiment Video
Updated: Aug 9, 2026

Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
Published on: March 18, 2012
The role of flavin-containing monooxygenases in drug metabolism and development
1Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92106, USA. JCashman@HBRI.org
Abstract:
This review discusses the role of the human flavin-containing monooxygenase in drug metabolism and drug development. The literature covered includes comprehensive reviews, as well as recent work that illustrates: (i) the role of flavin-containing monooxygenase in drug metabolism; (ii) its use for enhancing drug candidate selection and lead optimization, and improving pharmaceutical properties; (iii) its use to avoid drug-drug interactions; and (iv) its application to animal models. Using optimal procedures for drug metabolism evaluation, understanding the chemical complexity of metabolites, using recombinant technologies and applying new methods that are successful in other fields will help advance this field of drug metabolism and development.
More Related Videos
10:44Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Published on: March 28, 2017
09:33Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
Published on: March 20, 2018
Related Concept Videos
Drug Metabolism: Phase I Reactions
Drug Metabolism: Phase II Reactions
Drug Biotransformation: Overview
Phase I Oxidative Reactions: Overview
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Pharmacogenetics of Drug Metabolism: Overview