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[Ocular function in beta-thalassemia patients].
Vestnik Oftalmologii
|July 1, 1992
Summary
Thalassemia patients exhibit diverse ocular changes, including vascular abnormalities and retinal damage, influenced by disease severity and treatment. Early detection of these eye conditions is crucial for effective management.
Area of Science:
- Ophthalmology
- Hematology
- Medical Genetics
Context:
- Thalassemia, a group of inherited blood disorders, affects red blood cell production.
- Ocular complications in thalassemia patients are significant but often underdiagnosed.
- Comprehensive eye examinations are vital for monitoring disease progression and treatment effects.
Purpose:
- To investigate the spectrum of ocular manifestations in patients with various forms of thalassemia.
- To correlate ophthalmic findings with disease severity, duration, and treatment history.
- To highlight the importance of ophthalmological assessment in thalassemia management.
Summary:
- Evaluated 118 thalassemia inpatients using visual acuity, perimetry, biomicroscopy, ophthalmoscopy, and angiography.
- Observed early conjunctival and retinal vascular changes (tortuosity, dilatation, irregular caliber) and later dystrophic/atrophic changes.
- Identified hyperpigmentation and angioid streaks associated with blood transfusions and hemosiderosis.
Impact:
- Findings emphasize the need for routine ocular screening in thalassemia patients.
- Provides a basis for understanding the pathogenesis of thalassemia-related eye disease.
- Informs treatment strategies for preventing or managing vision-threatening ocular complications.