Related Experiment Video
Updated: Sep 20, 2026

Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays
Published on: June 18, 2016
cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection
Shweta Saran1, Marcel E Meima, Elisa Alvarez-Curto
1School of Life Sciences, University of Dundee, MSI/WTB complex, Dundee DD1 5EH, UK.
Abstract:
cAMP plays a pivotal role in control of cell movement, differentiation and response to stress in all phases of the Dictyostelium life cycle. The multitudinous functions of cAMP require precise spatial and temporal control of its production, degradation and detection. Many novel proteins have recently been identified that critically modulate the cAMP signal. We focus in this review on the properties and functions of the three adenylyl cyclases and the three cAMP-phosphodiesterases that are present in Dictyostelium, and the network of proteins that regulate the activity of these enzymes. We also briefly discuss the two modes of detection of cAMP.
Related Concept Videos
Gene Regulation During Sporulation
DNA Damage can Stall the Cell Cycle
MAPK Signaling Cascades
Positive Regulator Molecules

