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Related Experiment Video

Updated: Jul 19, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Murine models of asthma.

J C Kips1, G P Anderson, J J Fredberg

  • 1Dept of Medical Genetics, Ghent University Hospital, De Pintelaan 185, B 9000 Gent, Belgium. johan.kips@rug.ac.be

The European Respiratory Journal
|September 4, 2003
PubMed
Summary

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Murine models offer insights into asthma pathogenesis and treatment, particularly for studying inhaled allergen responses. However, researchers must carefully consider their limitations and focus on modeling specific asthma traits, especially lung function changes.

Area of Science:

  • Immunology
  • Pulmonology
  • Animal Models

Background:

  • In vivo animal models are crucial for understanding asthma.
  • Mice are increasingly utilized due to advanced immunological tools and gene deletion capabilities.
  • These models aid in investigating factors influencing responses to inhaled allergens.

Purpose of the Study:

  • To highlight the utility of mouse models in asthma research.
  • To address the limitations of current murine asthma models.
  • To guide the development and interpretation of asthma models in mice, focusing on lung function.

Main Methods:

  • Review of existing literature on murine asthma models.
  • Discussion of immunological tools applicable in mice.
  • Analysis of lung structure and function relevant to asthma.

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Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
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Related Experiment Videos

Last Updated: Jul 19, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
08:16

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
08:58

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

Main Results:

  • Mice allow detailed study of T-helper cell type 2 responses, T-cell trafficking, and innate immunity.
  • No single mouse model fully replicates the human asthma phenotype.
  • Models should focus on specific aspects of asthma, particularly changes in lung function.

Conclusions:

  • Mouse models are valuable for specific asthma research questions.
  • Careful consideration of model limitations is essential for valid results.
  • Developing models that accurately mimic asthma-related lung function changes is a key goal.