Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adoptive immunotherapy for malignant glioma.

Duane A Mitchell1, Peter E Fecci, John H Sampson

  • 1Department of Pathology and Department of Surgery, Duke University Medical Center, Box 3807, Durham, NC 27710, USA.

Cancer Journal (Sudbury, Mass.)
|September 4, 2003
PubMed
Summary

Adoptive T-cell therapy offers a promising immunotherapy approach for malignant brain tumors. This method harnesses a patient's T cells to target and destroy cancer cells, potentially improving outcomes without harming healthy brain tissue.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving Immune Checkpoint Blockade Efficacy in Melanoma Brain Metastases through Myddosomal inhibition with Emavusertib.

Molecular cancer therapeutics·2026
Same author

Real-world mortality and the effect of comorbidities on survival in glioblastoma: A database study using computed phenotypes for rapid, reliable patient identification.

Neuro-oncology advances·2026
Same author

Adoptive cellular therapy prevents reconstitution of myeloid-derived suppressor cells in the glioma tumor microenvironment.

Neuro-oncology advances·2026
Same author

A surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8<sup>+</sup> infiltration in glioma.

Scientific reports·2025
Same author

IL-7-mediated expansion of autologous lymphocytes increases CD8<sup>+</sup> VLA-4 expression and accumulation in glioblastoma models.

bioRxiv : the preprint server for biology·2025
Same author

A Rare Presentation of Adult Primary Leptomeningeal Medulloblastoma: Case Report.

Case reports in pathology·2025

Area of Science:

  • Neuro-oncology
  • Immunology
  • Cancer Therapy

Background:

  • Malignant brain tumors have a poor prognosis despite advances in treatment.
  • Current therapies often cause significant neurological deficits due to lack of specificity.
  • Immunotherapy presents a targeted treatment strategy for brain tumors.

Purpose of the Study:

  • To explore adoptive T-cell therapy as a potent immunotherapy for malignant brain tumors.
  • To highlight the potential of T cells in recognizing and eliminating tumor cells.
  • To discuss advancements enabling clinical translation of T-cell-based therapies.

Main Methods:

  • Leveraging T cells' natural ability to identify and destroy tumor cells.
  • Amplifying the patient's own T cells for enhanced anti-tumor activity.

Related Experiment Videos

  • Utilizing breakthroughs in T-cell activation, function, and tumor antigen discovery.

    • Main Results:

    • T cells can specifically recognize and mediate the destruction of malignant tumor cells.
    • Adoptive T-cell therapy aims to eradicate tumors while sparing normal brain tissue.
    • Advancements enhance the potential for effective residual tumor elimination.

    Conclusions:

    • Adoptive T-cell therapy holds significant promise for treating malignant brain tumors.
    • This immunotherapy approach offers targeted tumor eradication with reduced side effects.
    • Ongoing research in T-cell immunology and antigen discovery is crucial for clinical success.