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Related Experiment Videos

Elevated circulating somatostatin levels in acromegaly.

M Arosio1, S Porretti, P Epaminonda

  • 1Institute of Endocrine Sciences, Ospedale S. Giuseppe, A.Fa.R., Milan, Italy. maura.arosio@unimi.it

Journal of Endocrinological Investigation
|September 4, 2003
PubMed
Summary

Acromegaly patients show higher fasting somatostatin (SS) levels, particularly SS-14, compared to healthy individuals. This hypersomatostatinemia may link excess growth hormone (GH) and IGF-I to gastrointestinal dysfunction in acromegaly.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolic Disorders

Background:

  • Growth hormone (GH) influences somatostatin (SS) synthesis and secretion.
  • The effect of chronic GH excess, as seen in acromegaly, on circulating SS levels is not well understood.
  • Circulating SS, primarily from the enteropancreas, exists in various forms (SS-14, SS-28) and impacts gastrointestinal functions.

Purpose of the Study:

  • To characterize fasting and postprandial plasma SS patterns in normal subjects and acromegalic patients.
  • To investigate the relationship between GH/IGF-I excess and circulating SS levels.
  • To explore the potential role of altered SS levels in gastrointestinal dysfunction in acromegaly.

Main Methods:

  • Measured fasting total SS and SS-28 in 16 acromegalic patients and 16 healthy controls.

Related Experiment Videos

  • Assessed SS levels post-standard meal in 12 patients and 12 controls.
  • Analyzed correlations between SS levels, IGF-I, and SS-14/SS-28 ratios.

    • Main Results:

    • Fasting SS and SS-28 levels were significantly elevated in acromegalic patients compared to controls.
    • A positive correlation was observed between IGF-I and SS levels in acromegalic patients.
    • The ratio of SS-14 to SS-28 was higher in acromegalic patients.
    • Postprandial SS response did not differ significantly between groups.

    Conclusions:

    • Fasting hypersomatostatinemia, primarily due to increased SS-14, characterizes acromegaly.
    • Excess GH/IGF-I may cause somatostatin hypersecretion.
    • Altered SS levels could contribute to gastrointestinal motility changes in acromegaly.