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Updated: Sep 20, 2026

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
Published on: August 9, 2019
Vascular permeability factors in steroid-sensitive nephrotic syndrome and focal segmental glomerulosclerosis
1Renal Research Laboratories, Manchester Institute of Nephrology and Transplantation, Royal Infirmary, Manchester M13 9WL, UK. paul.brenchley@man.ac.uk
Abstract:
The concept that some forms of proteinuria may be induced by the action of circulating systemic permeability factors on the glomerular capillary wall is intriguing. First proposed in the 1970s in the context of steroid-sensitive nephrotic syndrome, the immune system was proposed as a source of such a vascular permeability factor (VPF). More recently, some forms of focal segmental glomerular sclerosis appear to be associated with another type of systemic factor. This paper reviews the evidence for such factors and compares the properties of a number of candidate VPFs.
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