Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recurrent disease in renal transplants.

Chas G Newstead1

  • 1Department of Renal Medicine, St James's University Hospital, Leeds, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|September 4, 2003
PubMed
Summary

Recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplant is common, especially in children. Early aggressive disease and prior graft recurrence predict transplant loss, while familial FSGS has a good prognosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alemtuzumab induction in renal transplantation permits safe steroid avoidance with tacrolimus monotherapy: a randomized controlled trial.

Transplantation·2013
Same author

The clinical significance of early proteinuria after renal transplantation.

Transplantation·2010
Same author

Poor tolerance of sirolimus in a steroid avoidance regimen for renal transplantation.

Transplantation·2008
Same author

Systemic lupus erythematosus, eosinophilic vasculitis and acalculous cholecystitis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2005

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Glomerular Diseases

Background:

  • Minimal change glomerulonephritis and FSGS can occur post-renal transplantation.
  • FSGS recurrence affects approximately 20% of kidney transplant recipients.
  • Predictive factors for FSGS recurrence include young age, aggressive disease course, and diffuse mesangial proliferation.

Purpose of the Study:

  • To review the occurrence, prediction, and management of FSGS recurrence post-kidney transplantation.
  • To differentiate between idiopathic and familial FSGS in the context of transplantation.
  • To assess the impact of FSGS recurrence on graft survival and compare outcomes with other glomerular disorders.

Main Methods:

  • Literature review of studies on FSGS recurrence after renal transplantation.

Related Experiment Videos

  • Analysis of factors influencing graft survival in pediatric and adult transplant recipients.
  • Evaluation of treatment strategies for recurrent FSGS.

    • Main Results:

    • Pediatric FSGS patients have significantly higher graft loss rates compared to those with structural disorders.
    • Recurrence in a subsequent graft is likely if the initial graft was affected.
    • Plasma exchange and cyclophosphamide are effective treatments for recurrent FSGS.

    Conclusions:

    • FSGS recurrence poses a significant risk to graft survival, particularly in pediatric recipients.
    • Familial FSGS is distinct from idiopathic FSGS and associated with better transplant outcomes.
    • Adults with secondary FSGS have a low risk of recurrence post-transplant.