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Updated: Sep 20, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Effects of developmental and adult androgens on male abdominal adiposity
Matthew H McIntyre1, Susan F Lipson, Peter T Ellison
1Harvard University, Department of Anthropology, Cambridge, Massachusetts 02138, USA. mmcintyr@fas.harvard.edu
Abstract:
We present results from 42 gay men who completed a survey including self-measurement of waist circumference, height, and weight, in addition to providing saliva samples for the assay of testosterone, and a photocopy of the right hand for the measure of second-to-fourth digit length ratio (2D:4D), proposed as a means of approximating androgenic effects during development. The analyses were conducted as a test of the recent hypothesis, proposed by Abbott et al. ([2002] J Endocrinol 174:1-5), that high prenatal androgen exposure causes greater deposition of fat on the abdomen relative to other depots. We found support for this hypothesis in men, albeit in a limited sample and with self-reported and self-collected data.
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