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A randomized comparison of three insemination methods in an artificial insemination program using husbands' semen
Ernest Hung Yu Ng1, Guneet Makkar, William Shu Biu Yeung
1Department of Obstetrics and Gynaecology, University of Hong Kong, 6/F, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, People's Republic of China. nghye@hkucc.hku.hk
The Journal of Reproductive Medicine
|September 5, 2003
Summary
Single intrauterine insemination (SIUI), double intrauterine insemination (DIUI), and fallopian tube sperm perfusion (FSP) demonstrated similar pregnancy rates in stimulated fertility cycles. This study found no significant differences in outcomes between these assisted reproductive techniques.
Area of Science:
- Reproductive Medicine
- Infertility Treatment
- Assisted Reproductive Technology
Background:
- Intrauterine insemination (IUI) and fallopian tube sperm perfusion (FSP) are assisted reproductive technologies used to treat infertility.
- Optimizing protocols for these procedures is crucial for improving pregnancy rates.
Purpose of the Study:
- To compare the efficacy of single intrauterine insemination (SIUI), double intrauterine insemination (DIUI), and fallopian tube sperm perfusion (FSP) in terms of pregnancy rates.
- To evaluate pregnancy rates per cycle and per patient, as well as multiple pregnancy rates and overall pregnancy outcomes.
Main Methods:
- A randomized controlled trial involving 90 patients undergoing standard ovarian stimulation.
- Patients were allocated to receive either SIUI, DIUI, or FSP.
- The study endpoint was defined as achieving pregnancy or completing 3 treatment cycles without conception.
Main Results:
- No significant differences were observed in demographic data or ovarian responses among the three groups.
- The total number of motile spermatozoa inseminated was lower in the FSP group compared to the SIUI group.
- Pregnancy rates per cycle and per patient, multiple pregnancy rates, and pregnancy outcomes were comparable across SIUI, DIUI, and FSP.
Conclusions:
- SIUI, DIUI, and FSP yield similar pregnancy rates when performed during stimulated fertility cycles.
- These findings suggest that all three methods are viable options for assisted reproduction under stimulated conditions.