[Simultaneous determination of three components in antongding injection by Kalman filtering method]

Area of Science:

• Analytical Chemistry
• Pharmaceutical Analysis

Context:

• Antongding injection is a pharmaceutical formulation requiring precise quantification of its active components.
• Traditional methods for analyzing multi-component injections often involve complex separation steps, increasing time and cost.

Purpose:

• To develop and validate a non-separation analytical method for determining amidopyrine, phenazone, and barbital in antongding injection.
• To assess the accuracy and precision of the Kalman filtering method for this pharmaceutical analysis.

Summary:

• The Kalman filtering method was successfully applied to quantify three key components (amidopyrine, phenazone, barbital) in antongding injection without prior separation.
• Excellent average recoveries (99.7-99.8%) and low relative standard deviations (0.82-1.5%) were achieved.
• Statistical analysis (t-test) confirmed no significant difference between the Kalman filtering method and standard analytical procedures.

Impact:

• Provides a more efficient and potentially cost-effective alternative for the quality control of antongding injection.
• Demonstrates the utility of the Kalman filtering method in complex pharmaceutical mixture analysis.
• Supports the development of advanced analytical techniques in pharmaceutical quality assurance.