Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perindopril pROtection aGainst REcurrent Stroke Study (PROGRESS): interpretation and implementation.

John Chalmers1, Stephen MacMahon

  • 1Institute for International Health, University of Sydney, Newtown, NSW, Australia. chalmers@iih.usyd.edu.au

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|September 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials.

Nature medicine·2026
Same author

Blood pressure parameters and cognitive decline and dementia after stroke or transient ischemic attack: results from the PROGRESS trial.

American journal of hypertension·2026
Same author

Blood pressure lowering for the prevention of REcurrent stroke and Cardiovascular outcomes After acute intracerebral haemorrhage: protocol for an individual Participant data meta-analysis of randomised controlled trials (RECAP-ICH).

Cerebrovascular diseases (Basel, Switzerland)·2026
Same author

Impact of Socioeconomic Status on Functional Outcome After Stroke in Ulaanbaatar, Mongolia.

Journal of the American Heart Association·2026
Same author

Optimal Definition of Early Neurological Deterioration in Thrombolysis-Treated Acute Ischemic Stroke: ENCHANTED Study.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same author

Effect of intensive blood pressure and blood glucose control on cardiovascular outcomes driven by reductions in cardiovascular death and nephropathy: Win ratio analysis of ADVANCE Trial.

European heart journal. Cardiovascular pharmacotherapy·2026
Same journal

Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

Hypertension and kidney alterations in rat offspring from low protein pregnancies.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
Same journal

Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
See all related articles

A perindopril-based blood pressure regimen significantly reduced stroke risk by 28% in patients with a history of stroke or transient ischaemic attack (TIA). Combination therapy with perindopril and indapamide offered greater benefits than monotherapy.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Pharmacology

Background:

  • Patients with a history of stroke or transient ischaemic attack (TIA) are at high risk for recurrent vascular events.
  • Effective blood pressure management is crucial for secondary prevention in these individuals.
  • The role of specific antihypertensive regimens, like those based on perindopril, requires further elucidation.

Purpose of the Study:

  • To evaluate the efficacy of a perindopril-based blood pressure lowering regimen in preventing recurrent stroke.
  • To assess the impact of this regimen on other major vascular events and cognitive decline.
  • To compare the effects in hypertensive versus non-hypertensive patients with a history of stroke or TIA.

Main Methods:

  • A randomized, placebo-controlled trial involving 6105 subjects across Asia, Australasia, and Europe.

Related Experiment Videos

  • Participants received either active treatment (perindopril-based regimen) or a placebo.
  • The primary outcome was the occurrence of total stroke (fatal or non-fatal); analysis was by intention to treat.

    • Main Results:

    • The perindopril-based regimen reduced blood pressure by 9/4 mmHg and significantly lowered the risk of total stroke by 28% (P < 0.0001).
    • Major vascular events, non-fatal myocardial infarction, cognitive decline, stroke-related dementia, and disability were also reduced.
    • Combination therapy with perindopril and indapamide yielded greater blood pressure and stroke risk reductions compared to perindopril monotherapy.

    Conclusions:

    • A perindopril-based blood pressure lowering regimen is effective in reducing stroke and other serious vascular events in patients with a history of stroke or TIA.
    • The benefits were observed in both hypertensive and non-hypertensive individuals.
    • Combination therapy with perindopril and indapamide should be considered for routine use in patients with a history of stroke or TIA.