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A tripeptidyl ensemble perspective of interactive control of growth hormone secretion
1Mayo Medical and Graduate School of Medicine, Mayo Clinic, Rochester, MN 55905, USA. veldhuis.johannes@mayo.edu
Hormone Research
|September 5, 2003
Abstract:
Current investigational tools in molecular biology, biochemistry and integrative physiology have revealed an increasing array of signals that influence growth hormone (GH) secretion. The present perspective combines these factors under a simplified final-common pathway model of threefold joint control by GH-releasing hormone, GH-releasing peptide/ghrelin and somatostatin. This concept is highlighted from the viewpoint of sex steroid- and age-dependent modulation of the peptide trilogy listed above.