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[Physiological and technical limitations of functional magnetic resonance imaging (fMRI)--consequences for clinical
T Wüstenberg1, K Jordan, F L Giesel
1Neurologische Klinik der Charité, Humboldt-Universität Berlin. torsten.wuestenberg@charite.de
Abstract:
Functional magnetic resonance imaging (fMRI) is the most common noninvasive technique in functional neuroanatomy. The capabilities and limitations of the method will be discussed based on a short review of the current knowledge about the neurovascular relationship. The focus of this article is on current methodical and technical problems regarding fMRI-based detection and localization of neuronal activity. Main error sources and their influence on the reliability and validity of fMRI-methods are presented. Appropriate solution strategies will be proposed and evaluated. Finally, the clinical relevance of MR-based diagnostic methods are discussed.