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Related Experiment Videos

In utero surgery for hydrocephalus.

Cornelia S von Koch1, Nalin Gupta, Leslie N Sutton

  • 1Department of Neurological Surgery, University of California San Francisco, Room M-779, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143-0112, USA. vonkochc@neurosurg.ucsf.edu

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|September 5, 2003
PubMed
Summary

Neonatal hydrocephalus, a common nervous system anomaly, can be detected early via ultrasound. Advances in fetal imaging and surgery may improve outcomes for selected fetuses through in utero intervention.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Neonatal hydrocephalus is a frequent congenital nervous system anomaly.
  • Early detection of fetal ventriculomegaly is possible with ultrasonography.
  • Current management includes termination, early delivery with shunting, or term delivery with shunting.

Observation:

  • Prolonged in utero hydrocephalus negatively impacts cognitive outcomes.
  • Early attempts at fetal intervention in the 1980s yielded poor results due to inadequate patient selection and surgical techniques.
  • A moratorium on fetal shunting was imposed following these early challenges.

Findings:

  • Recent advancements in fetal imaging (e.g., MRI) enhance diagnostic accuracy.
  • Progress in fetal surgical techniques offers improved intervention possibilities.

Related Experiment Videos

  • Properly selected fetuses with hydrocephalus may benefit from in utero treatment.

    • Implications:

    • Improved fetal imaging and surgical methods may lead to better outcomes for congenital hydrocephalus.
    • Careful patient selection is crucial for successful fetal intervention.
    • In utero intervention presents a potential alternative to postnatal treatment for select cases.