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[Acute early rejection in renal transplantation]
R García1, L Rubio, C Henríquez-La Roche
1Servicio de Nefrología, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela.
Investigacion Clinica
|January 1, 1992
Summary
Kidney transplant recipients receiving cadaver kidneys had higher early acute rejection rates. However, this rejection did not impact long-term graft survival or patient outcomes.
Area of Science:
- Nephrology
- Transplant Surgery
- Immunology
Context:
- Evaluating early acute rejection in kidney transplant recipients.
- Analyzing outcomes based on donor type (cadaver vs. living).
- Assessing the impact of triple immunosuppression therapy.
Purpose:
- To determine the incidence of early acute rejection in kidney transplant recipients.
- To compare rejection rates between cadaver and living donor kidney transplants.
- To evaluate the influence of early rejection on graft survival, patient survival, and graft function.
Summary:
- A study of 150 kidney transplant recipients found a significantly higher incidence of early acute rejection (first two months) in those receiving cadaver donor kidneys (34%) compared to living donor kidneys (19.6%).
- Most patients (142) received triple immunosuppression therapy (cyclosporine, prednisone, azathioprine).
- Despite the higher incidence in cadaver transplants, early acute rejection did not significantly affect graft or patient survival or long-term graft function.
Impact:
- Early acute rejection in kidney transplantation is more common with cadaver donors but does not appear to compromise long-term graft or patient survival.
- Findings suggest that current immunosuppression protocols may mitigate the negative effects of early rejection episodes.
- Highlights the importance of donor source in immediate post-transplant outcomes while reassuring about long-term prognosis.