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Glucose-6-phosphate dehydrogenase (G-6-PD) levels in jaundiced neonates in Calabar

E K Uko1, S N Agwunobi, J J Udoh

  • 1Department of Haematology, University of Calabar, Nigeria.

Nigerian Journal of Medicine : Journal of the National Association of Resident Doctors of Nigeria
|September 6, 2003
PubMed

Insights

Neonatal jaundice is often linked to low glucose-6-phosphate dehydrogenase (G-6-PD) activity. Routine G-6-PD testing in jaundiced infants is recommended to identify deficiency and prevent complications.

Area of Science:

  • Biochemistry
  • Neonatal Medicine
  • Hematology

Background:

  • Glucose-6-phosphate dehydrogenase (G-6-PD) is crucial for NADPH generation in red blood cells.
  • Neonates with G-6-PD deficiency are at risk for severe hemolytic anemia and jaundice.
  • Understanding the association between G-6-PD levels and neonatal jaundice is critical for early diagnosis and management.

Purpose of the Study:

  • To investigate the relationship between neonatal jaundice and G-6-PD enzyme activity.
  • To determine the prevalence and degree of G-6-PD deficiency in jaundiced neonates.

Main Methods:

  • A study was conducted on 102 jaundiced neonates admitted to the Special Care Baby Unit.
  • G-6-PD levels were measured using a diagnostic assay kit.
  • Data analysis was performed using SPSS software.

Main Results:

  • 38.2% of jaundiced neonates exhibited G-6-PD deficiency, with significantly lower enzyme concentrations.
  • The overall prevalence of G-6-PD deficiency among the studied jaundiced neonates was 38%.
  • No significant gender-based differences in G-6-PD levels were observed.

Conclusions:

  • Low G-6-PD activity is prevalent in jaundiced neonates.
  • Routine G-6-PD level assays are recommended for all jaundiced infants.
  • Early detection of G-6-PD deficiency can aid in managing neonatal jaundice.
Abstract

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