Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum hepcidin in clinical specimens.

Gail Dallalio1, Thomas Fleury, Robert T Means

  • 1Hematology Oncology Division, Department of Medicine, Ralph H. Johnson VA Medical Center and the Medical University of South Carolina, Charleston, SC 29425, USA. meansr@musc.edu

British Journal of Haematology
|September 6, 2003
PubMed
Summary

Serum hepcidin levels correlate with ferritin but not other iron status markers in anemia patients. Further research is needed to understand serum hepcidin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Somatic Mutations in Acquired Pure Red Cell Aplasia: Incidence and Implications.

American journal of hematology·2026
Same author

Macrocytes in hemochromatosis: associations of a common finding in a common disease.

The American journal of the medical sciences·2026
Same author

Management of iron deficiency in children, adults, and pregnant individuals: evidence-based and expert consensus recommendations.

The Lancet. Haematology·2025
Same author

Ferritin reference intervals in a population of working-age adults without anemia.

American journal of hematology·2024
Same author

New molecular approaches to "the first molecular disease".

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2024
Same author

Pure red cell aplasia: The second hundred years.

The American journal of the medical sciences·2023

Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Medicine

Background:

  • Hepcidin, a hepatic antimicrobial protein, regulates iron absorption and mobilization.
  • Hepcidin gene overexpression is linked to hypoferremic, microcytic, iron-refractory anemia.
  • Hepcidin is hypothesized to mediate anemia of chronic disease (ACD).

Purpose of the Study:

  • To investigate the correlation between serum hepcidin concentrations and iron status markers in anemic patients.
  • To evaluate the potential of serum hepcidin as a diagnostic marker for anemia.

Main Methods:

  • Serum hepcidin concentrations were measured in 55 specimens submitted for ferritin determination.
  • Serum hepcidin was also measured in 37 specimens from anemic patients undergoing bone marrow examination.

Related Experiment Videos

  • Statistical analysis was performed to assess correlations with ferritin and other iron status markers.

    • Main Results:

    • Serum hepcidin concentration showed a statistically significant correlation with serum ferritin levels in both patient groups.
    • No significant correlations were found between serum hepcidin and other laboratory markers of iron status or anemia diagnosis.
    • Serum hepcidin did not correlate as well with clinical diagnosis as urinary hepcidin.

    Conclusions:

    • Serum hepcidin levels are significantly associated with serum ferritin concentrations.
    • Serum hepcidin may not be a reliable sole indicator for diagnosing anemia or assessing iron status.
    • Further investigation into hepcidin clearance and metabolism is required to elucidate its role in ACD pathogenesis.