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Bipolar disorders during adolescence.

P M Lewinsohn1, J R Seeley, D N Klein

  • 1Oregon Research Institute, Eugene, OR 97403, USA.

Acta Psychiatrica Scandinavica. Supplementum
|September 6, 2003
PubMed
Summary
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Bipolar disorder (BD) and milder forms almost always begin in adolescence, leading to significant impairment and risks for future mood disorders. Early intervention for adolescent BD is crucial for public health.

Area of Science:

  • Child and Adolescent Psychiatry
  • Mood Disorders Research
  • Mental Health Epidemiology

Background:

  • Bipolar disorder (BD) and subthreshold presentations are significant concerns in adolescent mental health.
  • Understanding the early course and familial patterns of these conditions is vital for effective intervention.

Purpose of the Study:

  • To investigate the incidence, associated factors, progression, and family history of bipolar disorder (BD) and subthreshold BD in adolescents.
  • To identify early indicators and long-term outcomes for adolescent BD spectrum disorders.

Main Methods:

  • Utilized structured diagnostic interviews in a large community sample of adolescents and their first-degree relatives.
  • Conducted longitudinal re-evaluations of adolescents into young adulthood to track disorder progression.

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Main Results:

  • Onset of BD and subthreshold BD predominantly occurred during adolescence, correlating with increased impairment, comorbidity, and suicide attempts.
  • Adolescents diagnosed with BD faced higher risks for developing BD in adulthood, while those with subthreshold BD were at increased risk for major depressive disorder (MDD).
  • Family history revealed elevated rates of subthreshold BD and MDD in relatives of adolescents with BD, and vice versa for relatives of those with subthreshold BD.

Conclusions:

  • Evidence confirms the existence of 'classical' bipolar disorder in adolescence, alongside a spectrum of milder bipolar conditions.
  • Addressing and preventing adolescent BD and related disorders is a critical public health priority requiring focused attention and resources.