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Vulnerability, destabilization and restitution in anxious depression
1Institute of Psychiatry, King's College, London, UK.
Acta Psychiatrica Scandinavica. Supplementum
|September 6, 2003
Abstract
Objective:
To summarize what is known about vulnerability and resilience to common mental disorders, and the psychosocial factors associated with speed of recovery.
Method:
Recent genetic factors are summarized, and taken together with known facts about social factors encouraging or reducing likelihood of an episode.
Results:
Multiple genes are likely, controlling both vulnerability and resilience, with the manifestation in phenotype modified by environmental factors. Restitution must be thought of separately from vulnerability.
Conclusion:
Instead of specific genes causing specific mental disorders, we need a more complex model.