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Involvement of second messengers and protein phosphorylation in astrocyte swelling
A S Bender1, J T Neary, M D Norenberg
1Laboratory of Neuropathology, Veterans Administration Medical Center, Miami, FL 33101.
Canadian Journal of Physiology and Pharmacology
|January 1, 1992
Abstract:
In a hypoosmotic model of astrocyte swelling, we found that Ca2+ and intracellular signals such as diacylglycerol and inositol phosphate, as well as protein phosphorylation systems, are implicated in the generation and (or) modulation of volume regulatory processes. Cyclic AMP, which also has a significant effect on astrocyte volume regulation, in addition influences some of these second messengers.