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Related Experiment Videos

Synaptic mechanisms in sympathetic preganglionic neurons.

N J Dun1, S Y Wu, E Shen

  • 1Department of Anatomy, Medical College of Ohio, Toledo 43699.

Canadian Journal of Physiology and Pharmacology
|January 1, 1992
PubMed
Summary

Sympathetic preganglionic neurons (SPNs) utilize diverse synaptic potentials, including excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs), mediated by various neurotransmitters like glutamate and glycine. These complex mechanisms ensure organized neural output.

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Area of Science:

  • Neuroscience
  • Neurophysiology

Background:

  • Sympathetic preganglionic neurons (SPNs) are crucial for autonomic nervous system function.
  • Understanding the synaptic mechanisms governing SPNs is essential for comprehending autonomic control.

Purpose of the Study:

  • To characterize the types and neurotransmitter mediators of synaptic potentials in SPNs.
  • To investigate the functional diversity of synaptic inputs to SPNs.

Main Methods:

  • Intracellular recordings from adult cat and neonatal rat spinal cord slices.
  • Pharmacological manipulations to identify neurotransmitter roles.

Main Results:

  • Identified excitatory postsynaptic potentials (EPSPs), inhibitory postsynaptic potentials (IPSPs), slow EPSPs, and slow inhibitory postsynaptic potentials (IPSPs).

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  • Glutamate and glycine are likely mediators for EPSPs and IPSPs, respectively.
  • Substance P, serotonin, norepinephrine, and epinephrine are implicated in slow EPSPs; norepinephrine in slow IPSPs.
  • Ventral root stimulation suggests glutamate release from afferent fibers.

    • Conclusions:

    • SPNs exhibit a wide array of synaptic mechanisms for processing sensory and supraspinal inputs.
    • These diverse synaptic inputs allow for highly organized yet differentiated outputs to peripheral targets.