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Related Experiment Videos

Twinning.

Judith G Hall1

  • 1Department of Paediatrics, 4480 Oak Street, Room 2D19, British Columbia's Children's Hospital, BC, V6H 3V4, Vancouver, Canada. jhall@cw.bc.ca

Lancet (London, England)
|September 6, 2003
PubMed
Summary
This summary is machine-generated.

Twin pregnancies, including monozygotic twins, are rising due to reproductive technologies. Both twin types show slower in-utero growth and may have distinct developmental programming compared to singletons.

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Area of Science:

  • Reproductive biology
  • Maternal-fetal medicine
  • Human genetics

Background:

  • Twinning, particularly monozygotic twins, has increased due to assisted reproductive technologies.
  • While dizygotic twinning is linked to hormonal factors, the causes of monozygotic twinning remain unclear.
  • Twin studies are valuable but require caution as twins may not represent singleton pregnancies.

Purpose of the Study:

  • To review current understanding of twin pregnancy frequency, complications, and long-term outcomes.
  • To explore the causes and implications of monozygotic and dizygotic twinning.
  • To highlight developmental differences in twins compared to singletons.

Main Methods:

  • Review of existing literature and technological advancements in twin studies.

Related Experiment Videos

  • Analysis of data on twin pregnancy frequency and associated complications.
  • Examination of developmental and biochemical programming in twin pregnancies.

    • Main Results:

    • Artificial reproductive technologies have significantly increased dizygotic and monozygotic twin rates.
    • Monozgotic twinning is associated with higher rates of spontaneous abortion and congenital anomalies.
    • Both twin types exhibit decelerated in-utero growth from 30 weeks and potential early developmental programming differences.

    Conclusions:

    • Monozgotic twinning may be an anomaly with inherent risks.
    • Twins may be developmentally and biochemically programmed differently from early pregnancy.
    • Further research is needed to understand the unique aspects of twin development and outcomes.