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Donald L Gardiner1, Tina S Skinner-Adams, Tobias Spielmann

  • 1Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, a joint program of the Queensland Institute of Medical Research and the School of Population Health, University of Queensland, Herston. donG@qimr.edu.au

Trends in Parasitology
|September 6, 2003
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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...