Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maturation, repair and aging of the arteries as reflected in the biochemistry of the arterial smooth muscle cell: Maturation, repair and aging of the arteries as reflected in the biochemistry of the arterial smooth muscle cell.

Scandinavian journal of clinical and laboratory investigation. Supplementum·2011
Same author

Proteinase Activity of Rat Lymph Nodes.

The Yale journal of biology and medicine·2011
Same author

LIPID SYNTHESIS, INTRACELLULAR TRANSPORT, AND STORAGE : III. Electron Microscopic Radioautographic Study of the Rat Heart Perfused with Tritiated Oleic Acid.

The Journal of cell biology·2009
Same author

III. Electron microscopic radioautographic study of the rat heart perfused with tritiated oleic acid.

The Journal of cell biology·2009
Same author

Lipid transfer proteins (LTP) and atherosclerosis.

Atherosclerosis·2005
Same author

Self-assembly and recrystallization of bacterial S-layer proteins at silicon supports imaged in real time by atomic force microscopy.

Journal of microscopy·2003

Related Experiment Video

Updated: Jul 21, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Lipoprotein lipase and atherosclerosis.

Y Stein1, O Stein

  • 1Lipid Research Laboratory, Division of Medicine, Hadassah University Hospital, P.O.B. 12 220, Jerusalem 91120, Israel. ystein@hadassah.org.il

Atherosclerosis
|September 6, 2003
PubMed
Summary

Lipoprotein lipase (LPL) has dual roles in atherosclerosis. While its catalytic function is antiatherogenic, non-catalytic functions are proatherogenic, impacting cardiovascular health.

Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Molecular Medicine

Background:

  • Lipoprotein lipase (LPL) is crucial for triglyceride metabolism and influences HDL levels, suggesting an antiatherogenic role.
  • However, LPL's non-catalytic functions, including lipoprotein bridging and selective cholesteryl ester uptake, are implicated in promoting atherosclerosis.

Purpose of the Study:

  • To evaluate the balance between LPL's pro- and antiatherogenic functions.
  • To review recent evidence from animal models and human genetic studies on LPL's role in atherosclerosis.
  • To incorporate new findings on nuclear receptor regulation of LPL.

Main Methods:

  • Review of evidence from transgenic animal models.
  • Analysis of studies on common LPL mutations in humans.

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Related Experiment Videos

Last Updated: Jul 21, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

  • Integration of recent data on nuclear receptors, ligands, and agonists in LPL regulation.

    • Main Results:

    • Evidence suggests a complex, dual role for LPL in atherogenesis, dependent on its catalytic and non-catalytic activities.
    • Transgenic animal studies and human mutation data provide insights into LPL's net effect on atherosclerosis.
    • Nuclear receptors and their modulators significantly influence LPL activity across different organs.

    Conclusions:

    • The net impact of LPL on atherosclerosis depends on the interplay between its opposing functions.
    • Understanding LPL regulation by nuclear receptors may offer therapeutic strategies.
    • Further research into LPL modulation could lead to novel treatments for cardiovascular disease.