Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging and angiogenesis.

Jay M Edelberg1, May J Reed

  • 1Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA. jme2002@mmed.cornell.edu

Frontiers in Bioscience : a Journal and Virtual Library
|September 6, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of Tonlamarsen in Patients With Uncontrolled Hypertension: The KARDINAL Phase 2 Randomized Clinical Trial.

Journal of the American College of Cardiology·2026
Same author

Lecanemab alters basement membrane collagen IV in viable microvessels isolated from brains with high Alzheimer's disease neuropathology.

Journal of Alzheimer's disease : JAD·2026
Same author

Comparative permeability of the blood-brain barrier to albumin, DTPA, and sucrose: effects of inflammation-induced disruption.

Fluids and barriers of the CNS·2025
Same author

Transport of CCL2 across an induced pluripotent stem cell-derived in vitro model of the human blood-brain barrier is heparan sulfate-dependent.

PloS one·2025
Same author

Danicamtiv, a Selective Agonist of Cardiac Myosin, for Dilated Cardiomyopathy: A Phase 2 Open-Label Trial.

Journal of the American College of Cardiology·2025
Same author

Communication Surrounding Treatment Preferences for Older Adults With Dementia During Emergency Medical Services Response.

Journal of the American Geriatrics Society·2025
Same journal

The CD44 protein family: roles in embryogenesis and tumor progression.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Four varieties of voltage-gated proton channels.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Lurie's tubercle-count method to test TB vaccine efficacy in rabbits.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Optical spectroscopy of breast biopsies and human breast cancer xenografts in nude mice.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

The colostrum-deprived, artificially-reared, neonatal pig as a model animal for studying rotavirus gastroenteritis.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Action of polypeptide growth factors in colon cancer; development of new therapeutic approaches.

Frontiers in bioscience : a journal and virtual library·2017
See all related articles

Aging impairs angiogenesis, the formation of new blood vessels, leading to worse vascular diseases in older adults. Strategies to improve blood vessel function must be disease-specific for older individuals.

Area of Science:

  • Biomedical Science
  • Gerontology
  • Vascular Biology

Background:

  • Aging is associated with impaired angiogenesis in tissues.
  • This deficit contributes to the increased severity of vascular diseases in older individuals.
  • Age-related changes in angiogenesis occur at molecular, cellular, and physiological levels.

Purpose of the Study:

  • To review the age-related changes in angiogenesis.
  • To discuss the clinical consequences of impaired neovascularization in aging.
  • To highlight the need for targeted clinical strategies for the aging vasculature.

Main Methods:

  • Review of molecular, cellular, and physiological regulatory components of angiogenesis.
  • Analysis of age-influenced factors including endothelial cells, hemostatic cascade, mediators, and growth factors.

Related Experiment Videos

  • Examination of alterations in the extracellular matrix scaffold in aged tissues.

    • Main Results:

    • Aging affects multiple components of the neovascular process.
    • Endothelial cells, hemostatic cascade, neuro-chemical mediators, growth factors, and matrix scaffold are altered with age.
    • These changes lead to delayed and impaired neovascularization in aged tissues.

    Conclusions:

    • Impaired angiogenesis in aging has detrimental effects on tissue repair and ischemic conditions.
    • Conversely, reduced neovascularization may inhibit tumor growth.
    • Clinical strategies to enhance vascular function in the elderly must be tailored to specific disease states.