Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumour occurrence and recurrence.

A L Ogilvy-Stuart1, S M Shalet

  • 1Department of Endocrinology, Christie Hospital and Holt Radium Institute, Manchester, UK.

Hormone Research
|January 1, 1992
PubMed
Summary

Therapeutic growth hormone (GH) use did not increase tumor recurrence in children treated for brain tumors. This study found no association between GH therapy and subsequent tumor recurrence in pediatric patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An outbreak of meticillin-resistant Staphylococcus aureus colonization in a neonatal intensive care unit: use of a case-control study to investigate and control it and lessons learnt.

The Journal of hospital infection·2019
Same author

Donor human milk for Muslim infants in the UK.

Archives of disease in childhood. Fetal and neonatal edition·2016
Same author

Extensive expertise in endocrinology: UK stance on adult GH replacement: the economist vs the endocrinologist.

European journal of endocrinology·2013
Same author

Validation of the continuous glucose monitoring sensor in preterm infants.

Archives of disease in childhood. Fetal and neonatal edition·2012
Same author

Long-term safety of growth hormone replacement after CNS irradiation.

The Journal of clinical endocrinology and metabolism·2011
Same author

With commentary.

Archives of disease in childhood·2010

Area of Science:

  • Pediatric Oncology
  • Endocrinology
  • Cancer Research

Background:

  • Concerns exist regarding the oncogenic potential of therapeutic growth hormone (GH).
  • Studies show mixed results: GH inducing tumors in rats, but lower incidence in hypophysectomized animals.
  • Acromegaly, characterized by high GH levels, is linked to increased cancer incidence, particularly colonic neoplasia.

Purpose of the Study:

  • To investigate if growth hormone (GH) treatment for radiation-induced GH deficiency increases tumor recurrence in children previously treated for brain tumors.

Main Methods:

  • Retrospective comparison of tumor recurrence rates in 47 children treated with GH versus 160 controls from a cancer registry.
  • Review of computerized tomography (CT) scans at GH initiation and follow-up.
  • Analysis included cases of acute lymphoblastic leukemia (ALL).

Main Results:

  • Five brain tumor recurrences were observed after GH therapy (1 astrocytoma, 2 ependymomas, 2 medulloblastomas).
  • Adjusted relative risk for tumor recurrence with GH use was 0.82 (95% CI: 0.28-2.37).
  • No statistically significant association was found between GH use and tumor recurrence across different tumor types.

Conclusions:

  • Growth hormone (GH) therapy in children treated for brain tumors does not appear to increase the risk of tumor recurrence.
  • Findings suggest GH can be safely used in this patient population.
  • Further research may be warranted to fully elucidate long-term oncogenic risks.

Related Experiment Videos