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Related Experiment Videos

Thyroid function during growth hormone therapy.

J O Jørgensen1, J Møller, N E Skakkebaek

  • 1Medical Department M (Endocrinology and Diabetes), Aarhus Kommunehospital, Denmark.

Hormone Research
|January 1, 1992
PubMed
Summary
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Growth hormone (GH) therapy enhances thyroid hormone conversion in GH-deficient adults, increasing triiodothyronine (T3) levels without impacting thyrotropin (TSH). This suggests GH influences peripheral thyroid hormone metabolism.

Area of Science:

  • Endocrinology
  • Metabolism
  • Thyroidology

Background:

  • Growth hormone (GH) administration in GH-deficient patients can affect thyroid function.
  • Previous studies reported varied effects, potentially due to uncontrolled designs or contaminated GH preparations.
  • Thyroid hormone levels, including thyroxine (T4) and triiodothyronine (T3), are crucial for metabolic regulation.

Purpose of the Study:

  • To investigate the effects of GH therapy on thyroid function in GH-deficient adults.
  • To clarify the impact of GH on thyrotropin (TSH) levels and peripheral T4 to T3 conversion.
  • To compare thyroid function during GH therapy versus placebo.

Main Methods:

  • A placebo-controlled crossover study involving GH-deficient adults, some on T4 substitution.

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  • Duration of GH therapy was 4 months, with subsequent analysis of thyroid function parameters.
  • Measurements included TSH, T4, T3 levels, and assessment of TSH response to TRH stimulation.

    • Main Results:

    • GH therapy significantly increased peripheral conversion of T4 to T3.
    • TSH levels and thyroidal secretion remained largely unaffected by GH administration.
    • T3 levels were lower during placebo treatment compared to healthy controls, indicating altered thyroid economy in GH deficiency.

    Conclusions:

    • GH therapy primarily enhances peripheral T4 to T3 conversion in GH-deficient adults.
    • The effect on thyroid hormone metabolism appears independent of significant changes in TSH secretion.
    • GH's role in thyroid hormone conversion may be linked to metabolic states rather than GH excess itself.