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Growth hormone and nutrition.

M L Vance1, M L Hartman, M O Thorner

  • 1Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908.

Hormone Research
|January 1, 1992
PubMed
Summary

Human growth hormone (GH) secretion involves more than just hypothalamic hormones. Numerous factors like nutrition, age, and body composition significantly influence GH release patterns.

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Ghrelin.

Molecular metabolism·2015

Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Human Physiology

Background:

  • Growth hormone (GH) secretion is primarily regulated by hypothalamic hormones: GH-releasing hormone (GHRH) and somatostatin (SS).
  • These hypothalamic hormones act as the final common pathway for various modulatory inputs influencing GH synthesis and secretion.
  • Understanding the complex regulatory network of GH secretion is crucial for human health and metabolic studies.

Purpose of the Study:

  • To provide a comprehensive overview of the multifaceted regulation of human growth hormone secretion.
  • To highlight the roles of various neuroendocrine, metabolic, and physiological factors beyond GHRH and somatostatin.
  • To emphasize the increasing clarity regarding the influence of nutritional status on GH secretion.

Main Methods:

  • Review and synthesis of existing scientific literature on growth hormone regulation.
  • Analysis of factors modulating GH secretion, including neurotransmitters, metabolic substrates, and hormones.
  • Examination of the impact of age, nutrition, and body composition on GH secretion patterns.

Main Results:

  • GH secretion is influenced by a complex interplay of factors, not solely GHRH and somatostatin.
  • Key modulators include neurotransmitters, glucose, insulin-like growth factor I, and gonadal steroids.
  • Age, nutritional status, and body composition are significantly associated with GH secretion dynamics.

Conclusions:

  • Human GH regulation is a complex neuroendocrine process involving numerous peripheral and central inputs.
  • Nutritional status is increasingly recognized as a critical determinant of GH secretion patterns.
  • Further research into these complex interactions is essential for a complete understanding of GH physiology.

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