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Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic

Yu Hua Fan1, Lei Zhang, Wynnie W M Lam

  • 1Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China.

Stroke
|September 6, 2003
PubMed
Abstract

Insights

Cerebral microbleeds (MBs) detected by MRI may increase the risk of subsequent intracerebral hemorrhage in patients with acute ischemic stroke. Further research is needed to confirm this finding in larger populations.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Cerebral microbleeds (MBs) on gradient-echo MRI indicate advanced microangiopathy.
  • MBs may signify an increased risk of bleeding events.

Purpose of the Study:

  • To investigate if MBs are a risk factor for future intracerebral hemorrhage (ICH) in patients with acute ischemic stroke.

Main Methods:

  • Prospective study of acute cerebral infarction patients using gradient-echo T2*-weighted MRI to detect MBs.
  • Follow-up for recurrent stroke, vascular events, and mortality.

Main Results:

  • 43 of 121 patients (35.5%) had MBs.
  • No significant difference in recurrent ischemic stroke rates.
  • A trend towards increased intracerebral hemorrhage risk in patients with MBs (9.3% vs 1.3%).
  • Two ICH events occurred at sites of baseline MBs.

Conclusions:

  • MBs may be a risk factor for subsequent ICH in ischemic stroke patients.
  • A larger cohort study is necessary to validate these findings.

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