Related Experiment Videos
[Identification of four new ceramides from Anthopleura pacifica]
Shu-yu Zhang1, Hai-feng Tang, Yang-hua Yi
1Resarch Center for Marine Drugs, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Aim:
To study the bioactive constituents from Anthopleura pacifica.
Methods:
Compounds were separated by Pyricularia oryzae bioassay-guided fractionation method with a combination of multi-chromatography. Their chemical structures were determined on the basis of spectral analysis and chemical evidence.
Results:
A portion showing activity against P. oryzae was obtained and from the portion four compounds were identified as N-hydroxyethyl-N-tetradecanoyl-(2S,3R)-octadecasphinga-4(E), 8(E)-dienine (a), N-hydroxyethyl-N-(9Z-hexadecenoyl)-(2S,3R)-octadecasphinga-4 (E), 8 (E)-dienine (b), N-hydroxyethyl-N-hexadecanoyl-(2S,3R)-octadecasphinga-4(E), 8 (E)-dienine (c) and N-hydroxyethyl-N-(13Z-docosenoyl-(2S,3R)-octadecasphinga-4(E), 8(E)-dienine(d).
Conclusion:
All the four compounds are new ceramides.