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[Determination of naoning pian by multi-wavelength linear regression method]
1College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China.
Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu
|September 10, 2003
Summary
This study introduces a multi-wavelength linear regression method for analyzing naoning pian. The assay accurately quantifies pyramidon and caffeine without prior separation, offering a simple and rapid analytical solution.
Area of Science:
- Analytical Chemistry
- Spectroscopy
Context:
- Pharmaceutical analysis requires accurate quantification of active ingredients.
- Naoning pian is a pharmaceutical formulation containing multiple active compounds.
- Simultaneous determination of multiple components in complex matrices is challenging.
Purpose:
- To develop and validate a multi-wavelength linear regression method for the simultaneous assay of pyramidon and caffeine in naoning pian.
- To assess the accuracy, precision, and efficiency of the proposed analytical method.
Summary:
- A multi-wavelength linear regression method was developed and implemented using a BASIC program for the assay of naoning pian.
- The method achieved high recoveries for pyramidon (98.03%-100.9%) and caffeine (97.77%-99.39%) with low relative standard deviations (RSD) of 1.0% and 0.61%, respectively.
- The assay allows for the determination of both components without the need for chromatographic separation, demonstrating simplicity and speed.
Impact:
- Provides a validated, rapid, and cost-effective analytical method for pharmaceutical quality control.
- Enables efficient analysis of naoning pian, potentially improving manufacturing processes and ensuring product consistency.
- Demonstrates the utility of multi-wavelength linear regression in complex pharmaceutical formulations.