Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thermo- and pH-responsive biodegradable poly(alpha-N-substituted gamma-glutamine)s.

Yoichi Tachibana1, Motoichi Kurisawa, Hiroshi Uyama

  • 1Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

Biomacromolecules
|September 10, 2003
PubMed
Summary

Researchers created a new biodegradable poly(amino acid) that changes its water solubility based on temperature and pH. This double stimuli-responsive material shows potential for advanced applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EGCG-Building Nanocarriers for Multitasking Drug Delivery: Design Principles, Therapeutic Opportunities, and Translational Challenges.

International journal of nanomedicine·2026
Same author

Real-Time Stress Visualization of Hydrogels Enabled by Supramolecularly Switched Stretch-Induced Phase Separation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Synergistic and Selective Antiproliferative Effects of Cafestol and a Hyaluronic Acid-Epigallocatechin Gallate Conjugate in Human Renal Cancer Cells.

International journal of molecular sciences·2026
Same author

A Reproducible Multichannel Synchronous Rapid Phosphopeptide Enrichment Strategy Enabled by Anisotropic Porous Chitosan-Based Arrays.

Analytical chemistry·2026
Same author

Design of bio-based lignin-TiO<sub>2</sub>/PVA composite films for active food packaging.

International journal of biological macromolecules·2026
Same author

Mechanically Soft Phase-Separated Gelatin/Hyaluronic Acid Hydrogels Support Long-Term Expansion of Human Mesenchymal Stem Cells While Preserving Multipotency.

International journal of molecular sciences·2026

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials

Background:

  • Stimuli-responsive polymers are crucial for advanced material applications.
  • Poly(gamma-glutamic acid) is a biodegradable polymer with potential for modification.
  • Developing materials with tunable phase transition properties is an active research area.

Purpose of the Study:

  • To synthesize and characterize novel double stimuli-responsive poly(alpha-N-substituted gamma-glutamine).
  • To investigate the influence of amino alcohol combinations on polymer properties.
  • To evaluate the sensitivity of the polymer's phase transition temperature to environmental stimuli.

Main Methods:

  • Synthesis of poly(alpha-N-substituted gamma-glutamine) via reaction of poly(gamma-glutamic acid) with amino alcohols.

Related Experiment Videos

  • Characterization of the resulting polymers.
  • Assessment of lower critical solution temperature (LCST) behavior in aqueous solutions.
  • Evaluation of pH sensitivity on the phase transition temperature.

    • Main Results:

    • Successful development of double stimuli-responsive poly(alpha-N-substituted gamma-glutamine).
    • Achieved a sharp lower critical solution temperature (LCST) in water, tunable by amino alcohol selection.
    • Demonstrated high sensitivity of the phase transition temperature to pH variations.
    • Confirmed the biodegradable nature of the synthesized poly(amino acid).

    Conclusions:

    • The developed poly(alpha-N-substituted gamma-glutamine) exhibits dual stimuli-responsive behavior (temperature and pH).
    • This material offers tunable phase transition properties, making it suitable for various applications.
    • The biodegradability and sensitivity to environmental cues position it as a promising biomaterial.