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Updated: Aug 13, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Molecular predictors of treatment and outcome in colorectal cancer
1Division of Medical Oncology, University of Southern California/ Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Suite 3450, Los Angeles, CA 90033, USA. iqbal@usc.edu
Abstract:
Understanding of the metabolism and mechanisms of resistance of tumors to chemotherapeutic agents is essential so that we can administer therapy to maximize response and minimize toxicity. In this review we describe molecular markers associated with fluoropyrimidine and platinum-based chemotherapy that may predict the outcome of therapy when patients are treated with these agents. We discuss the ways in which determination of gene expression levels can enhance the treatment of colorectal cancer through prediction of patient response and tailoring of chemotherapy to the characteristics of an individual tumor.
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