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Updated: Sep 20, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
Virus infection and apoptosis (issue I). Dedicated to the memory of Lois K. Miller
Abstract:
Apoptosis is a highly regulated programmed cell death process, which is activated during normal development and by various stimuli that disturb cellular metabolism and physiology. It is a fundamental cellular process that has become a major focus of basic biomedical research. Due to the cell's innate ability to self-destruct, apoptosis is also an important mechanism of host response to viral infection. While there is an enormous amount of literature on the molecular aspects of cellular apoptosis, the field of apoptosis during viral infection is still in its infancy. The goal of this series of review articles is to critically evaluate the existing knowledge of viral infection and apoptosis in important fields of virology. The next several years should be very fruitful in this nascent research area.
Insights
Programmed cell death, or apoptosis, is crucial for development and host defense against viral infections. Research on apoptosis during viral infection is emerging, with this review series aiming to consolidate current knowledge.
Area of Science:
- Biomedical research
- Cellular biology
- Virology
Background:
- Apoptosis is a regulated, programmed cell death process vital for development and homeostasis.
- Cells utilize apoptosis for host defense mechanisms, including combating viral infections.
- While cellular apoptosis is well-studied, its role in viral pathogenesis is less understood.
Discussion:
- This review series critically evaluates the intersection of viral infection and apoptosis.
- It aims to synthesize existing knowledge in key areas of virology.
- The focus is on understanding how viruses manipulate or are targeted by apoptosis.
Key Insights:
- Apoptosis is a fundamental cellular process with implications for host-pathogen interactions.
- Viral infections can trigger or evade apoptosis, impacting disease progression.
- Understanding this interplay is critical for developing antiviral strategies.
Outlook:
- The field of apoptosis in viral infection is rapidly advancing.
- Future research will likely uncover novel mechanisms and therapeutic targets.
- This nascent area promises significant breakthroughs in virology and medicine.
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