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Related Experiment Videos

Controlling for potential confounding by occupational exposures.

Jack Siemiatycki1, Daniel Krewski, Yuanli Shi

  • 1Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada. j.siemiatycki@umontreal.ca

Journal of Toxicology and Environmental Health. Part A
|September 10, 2003
PubMed
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Occupational exposures do not significantly distort air pollution mortality studies. Reanalysis confirmed original findings, suggesting adequate control for job-related risks in air quality research.

Area of Science:

  • Environmental Epidemiology
  • Occupational Health
  • Public Health

Background:

  • Occupational exposure is a potential confounder in air pollution research.
  • Previous studies may have inadequately controlled for occupational variables.
  • Individuals in polluted areas may also work in polluted environments.

Purpose of the Study:

  • To reanalyze air pollution mortality data with improved control for occupational confounding.
  • To assess the impact of job "dirtiness" and occupational lung carcinogen exposure on study results.
  • To evaluate potential effect modification by occupational exposures.

Main Methods:

  • Supplemented original data with "dirtiness" and occupational lung carcinogen exposure indicators.
  • Used job titles and expert judgment to assign occupational variables.

Related Experiment Videos

  • Applied Cox proportional-hazards models, identical to original analyses.
  • Included new occupational covariates in statistical models.

    • Main Results:

    • Inclusion of occupational variables did not materially alter the original study findings.
    • Original results regarding air pollution and mortality appear robust.
    • Some inconsistent evidence suggested a potentially greater air pollution effect on mortality for subjects in "dirty" jobs.

    Conclusions:

    • Inadequate control of occupational variables likely did not distort the original air pollution study results.
    • The study's conclusions on air pollution and mortality remain valid.
    • Occupational factors may play a role in modifying the effects of air pollution, warranting further investigation.