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gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
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Sensitivity of BRCA1/2 mutation testing in 466 breast/ovarian cancer families

D G R Evans1, M Bulman, K Young

  • 1Academic Unit of Medical Genetics, Regional Genetics Service, and National Genetics Reference Laboratory, St Mary's Hospital, Manchester M13 0JH, UK. gareth.evans@cmmc.nhs.uk

Journal of Medical Genetics
|September 10, 2003
PubMed
Abstract

No abstract available in PubMed .

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...