Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antimicrobial polypeptides.

Tomas Ganz1

  • 1David Geffen School of Medicine, University of California, Los Angeles, CA, USA. tganz@mednet.ucla.edu

Journal of Leukocyte Biology
|September 10, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms of resistance to Tmprss6 antisense oligonucleotides in a mouse model of β-thalassemia.

Blood·2026
Same author

Plasma Hepcidin as a Prognostic Biomarker in Obese and Nonobese Patients With Early Breast Cancer: A Pooled Analysis of Two Prospective Cohort Studies.

Clinical breast cancer·2026
Same author

Halofuginone suppresses hepcidin by a heparan sulfate-dependent mechanism to treat iron disorders in mice.

Blood advances·2026
Same author

Disease-modifying effects of iron deficiency in mouse models of chronic renal failure.

Blood. Red cells & iron·2026
Same author

VHL, transferrin, and erythropoietin in the regulation of hepcidin.

HemaSphere·2025
Same author

A proposed path to explaining the unexplained anemia of aging.

The journals of gerontology. Series A, Biological sciences and medical sciences·2025

Respiratory secretions contain antimicrobial components that protect the airways from inhaled microbes. This review updates our understanding of these vital immune defenses.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Microbiology

Background:

  • The respiratory tract is a major portal of entry for inhaled microbes.
  • Respiratory secretions contain various antimicrobial substances, including lysozyme, first described by Alexander Fleming.
  • These secretions are produced by multiple cell types, including airway epithelial cells and phagocytes.

Purpose of the Study:

  • To provide an updated summary of the antimicrobial components in respiratory secretions.
  • To review the complex interactions of these components in host defense.
  • To highlight the current understanding of respiratory tract immunity.

Main Methods:

  • Literature review of existing research on respiratory antimicrobial components.
  • Synthesis of findings from previous studies and recent discoveries.

Related Experiment Videos

  • Analysis of the roles of various immune cells and molecules.

    • Main Results:

    • Identification of numerous antimicrobial polypeptides and other substances in respiratory secretions.
    • Elucidation of the synergistic and complex interactions among these components.
    • Recognition of the critical role of these secretions in innate respiratory immunity.

    Conclusions:

    • Respiratory secretions are crucial for defending the airways against microbial invasion.
    • Ongoing research continues to uncover novel antimicrobial factors and their mechanisms.
    • A comprehensive understanding of these defenses is vital for treating respiratory infections.