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The cannabinoid system and immune modulation.

Thomas W Klein1, Cathy Newton, Kellie Larsen

  • 1University of South Florida, College of Medicine, Department of Medical Microbiology and Immunology, Tampa 33612, USA. tklein@hsc.usf.edu

Journal of Leukocyte Biology
|September 10, 2003
PubMed
Summary
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The endocannabinoid system, involving CB1 and CB2 receptors, regulates brain-immune interactions. This system

Area of Science:

  • Neuroimmunology
  • Endocrinology

Background:

  • Marijuana research led to the discovery of the endocannabinoid system.
  • This system comprises CB1 and CB2 receptors and endogenous ligands like anandamide.
  • CB1 receptors are in the brain and periphery; CB2 receptors are mainly in immune cells.

Purpose of the Study:

  • To describe the endocannabinoid system and its components.
  • To explore the role of cannabinoids in modulating immune cell functions.
  • To investigate the involvement of the endocannabinoid system in the brain-immune axis.

Main Methods:

  • Review of studies on marijuana smoking and the endocannabinoid system.
  • Description of cannabinoid receptor types, ligands, and distribution.
  • Analysis of cannabinoid effects on immune cell functions and T helper cell development.

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Main Results:

  • Cannabinoid receptors are G protein-coupled receptors involved in signaling pathways.
  • Cannabinoids modulate immune cell functions, T helper cell development, chemotaxis, and tumor development.
  • These effects are mediated by cannabinoid receptor signaling and cytokine modulation.

Conclusions:

  • The immunocannabinoid system plays a role in regulating the brain-immune axis.
  • The endocannabinoid system presents potential therapeutic targets for immune deficiencies and chronic diseases.